Making The Sweetest Compound Known (Lugduname)
It’s here! Lugduname, the sweetest compound ever discovered. It is possible other undiscovered compounds are even more sweet. I suspect one of them might be a modified version of Lugduname. Since computing power and receptor modeling has come into existence since its discovery, it is possible we can model a molecule that has more affinity to the receptor. However, quantum computing is likely to give an easier answer to much of chemistry's problems.
Find me on / chemiolis
It is fair to consider that a sweetener of this potency will give the maximum sweetness that the body is capable of signaling when tasted directly. That is why they are tested as solutions in water, because our body cannot measure above the maximum amount of receptors/signaling (It is possible we perceive maximum sweetness even before all receptors are activated).
Don't conduct any chemical reactions without proper and professional safety analysis and risk management. Measures taken can be invisible, not filmed, not properly visible on camera or misjudged by the viewer due to setup or video construction. Always conduct own appropriate measures regardless of video setup.
Literature:
test in pigs
https://sci-hub.se/https://doi.org/10...
2,3-dihydroxybenzaldehyde via o-vanillin + acetic acid + hbr
https://sci-hub.se/https://doi.org/10...
Methylenedioxy aldehyde
https://sci-hub.se/https://doi.org/10...
Oxime
http://koreascience.or.kr/article/JAK...
https://www.rsc.org/suppdata/ob/c2/c2...
Oxime & Amine
https://onlinelibrary.wiley.com/actio...
Biphasic isothiocyanate synth
https://sci-hub.se/https://doi.org/10...
T-Bu Gly (for boiling point)
https://www.orgsyn.org/demo.aspx?prep...
review about thioureas to guanidines
https://www.arkat-usa.org/get-file/19...
HgCl2 guanylation
https://sci-hub.se/https://doi.org/10...
https://www.sciencedirect.com/science...
(alternative) aq phosphoric acid deprotect of t-bu ester
https://sci-hub.se/https://doi.org/10...
trisub guanidine acetic acids
https://pubs.acs.org/doi/pdf/10.1021/...
https://sci-hub.se/https://doi.org/10...
synth of trisub guanidines (only with aryl-carbonyl group)
https://pubmed.ncbi.nlm.nih.gov/30913...
https://sci-hub.se/10.1016/j.ejmech.2...
makes disubstituted guanidines
https://sci-hub.se/https://doi.org/10...
https://pubs.acs.org/doi/suppl/10.102...
Makes some guanidines, purifies them with flash column using 100 DCM 1 Methanol
https://sci-hub.se/https://doi.org/10...
Guanidines, Mentions regular column chromatography with 100% EtOAc
https://sci-hub.se/https://doi.org/10...
Mentions columning with 50% EtOAc
https://www.sciencedirect.com/science...
https://ars.els-cdn.com/content/image...
Patent for these sweeteners
https://worldwide.espacenet.com/paten...