Gabapentin 300mg, what it is used for, for neuropathic pain

Опубликовано: 31 Июль 2026
на канале: MEDICINE ONLINE TV

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GABAPENTIN 300MG, 400MG
MECHANISM OF ACTION:
1. Increased production of GABA, a major inhibitory neurotransmitter in the central nervous system. Its main function is to reduce neuronal excitability, promoting calm and relaxation.
2. Decreased GLUTAMATE, acting as the main excitatory neurotransmitter. It is essential for communication between nerve cells, memory, and learning.
INDICATIONS
Partial seizures
 Neuropathic pain. Trauma, accidents, or surgeries
 Rheumatoid arthritis or systemic lupus erythematosus
 Diabetes mellitus (10 years after first diagnosis)
 Alcoholism, long-term ED
 Toxicity (arsenic, ethylene oxide, thallium)
Neuropathic pain symptoms
• Shooting, burning, stabbing pain
• Numbness, paresthesia
• Burning, tingling
CONTRAINDICATIONS:
 Allergy or hypersensitivity
 Dizziness, vertigo
 Kidney failure, blood dyscrasias, during pregnancy and breastfeeding
 Risk of falls, confusion, loss of consciousness, progressive mental impairment
DRUG AND OTHER INTERACTIONS:
 Morphine increases plasma concentrations of Gabapentin
 Antacids such as milk of magnesia and Mylanta decrease absorption. (Take every 2 hours.)
ADVERSE REACTIONS
• Drowsiness.
• Tiredness or weakness.
• Dizziness, headache.
• Uncontrollable tremors in a part of your body.
• Double or blurred vision.
• Loss of balance, anxiety.
DOSAGE AND ROUTE OF ADMINISTRATION:
Start at a low dose. 300 mg daily, then gradually increase.