If you play Fate & Fortune you will lose time inside of the ghosts and skulls machine for the perkaholic. You would lose a ton of time for Fate only as you have to do the entire Easter egg first. If you plan on practicing a high round run, I would recommend doing G&S as it is easy enough to complete and does make the run easier if you use Skull Hacker. However If you get good at running the fast strategies I would recommend not doing G&S to save time for the higher rounds.
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