In this video, we will review an inexpensive PCIe-USB quad-controller card with great IOMMU separation.
You'd still need a platform that provides a decent IOMMU separation like X99/X299 or AMD Threadripper or Ryzen with ACS enabled in BIOS.
These are some links that list the card.
https://www.xt-xinte.com/XT-XINTE-USB...
https://www.ebay.com/itm/XT-XINTE-PCI...
https://www.aliexpress.com/item/40004...
https://www.aliexpress.com/item/40004...