When panels are connected in series, the voltage is increased by each additional panel. For instance, twelve panels of 41 volts OC each is 492 volts. Whatever the voltage is of your panels, make sure that your charge controller can handle it. If panels are connected in parallel, the voltage will stay the same as just one panel, but the amps are increased with each additional panel. Twelve panels of 370 watts each equals 4440 watts. To determine the amps, simply divide the watts by the voltage of your battery bank. If your battery bank is 48 volts, then divide the watts (4440) by the volts (48) to get 92.5 amps. In this example, your charge controller will have to handle 492 volts and 92.5 amps. If not, it will fail.
Panels can be connected in multiple series strings that are then connected in parallel, to reduce either amps or volts in order to not blow your controller.
Most off-grid systems of enough size to operate a home, will utilize a hybrid controller inverter, which can be connected in parallel with other units to increase power production. For instance, if your home requires 5000 watts and your shop requires another 5000 watts, you can power both systems with the same panels by connecting two 5000 watt controller inverters in parallel. Depending on the inverter, you can get 120 VAC, 220 VAC, three phase or all three.