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Hormonal imbalance: Hormonal imbalances can accompany hyperpigmentation, as seen in melasma during pregnancy and in women undergoing hormonal treatment such as taking birth control pills. Excessive sun exposure: Prolonged and intense sun exposure contributes to the formation of hyperpigmentation spots. Skin inflammation: The skin's healing process after inflammation is accompanied by the production of large amounts of melanin, which causes the appearance of hyperpigmentation spots. The more severe the inflammation, the darker and larger the hyperpigmentation will be. Drug interactions: Some medications, such as tricyclic antidepressants and antimalarials, can cause hyperpigmentation, which turns gray. Certain topical creams can also cause hyperpigmentation spots. Medical conditions: Some diseases can cause hyperpigmentation spots, including: Addison's disease: Addison's disease, which involves adrenal gland dysfunction, can cause the body to produce excessive amounts of melanin. Hemochromatosis: Hemochromatosis causes high iron levels in the blood, resulting in darker skin.
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