Extracellular vesicles in Parkinson’s disease
Tiago Outeiro, PhD, University Medical Center Göttingen, Göttingen, Germany, discusses the growing interest in extracellular vesicles (ECVs) as a research and clinical tool in Parkinson’s disease. ECVs containing diverse contents are released from cells and thus participate in a plethora of biological processes. Key functions include waste removal and facilitating cell-to-cell communication by delivering cargo to recipient cells. It has been suggested that ECVs in the central nervous system could play a role in Parkinson’s disease through the transport of alpha synuclein. Studying the cargo, mechanisms of release, and impacts of cell-to-cell communication on recipient cells could shed light on disease pathophysiology, as well as identifying potential biomarkers and intervention targets. Prof. Outeiro outlines his work looking into the release of different proteins implicated in neurodegenerative diseases and their onward journeys. This interview took place at The BNA 2023 International Festival of Neuroscience in Brighton, UK.
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