Comparative Genome Analysis of E. coli Strain Sanji
E. coli strain Sanji is the first sequenced and analyzed genome of the recently emerged pathogenic XDR strains with sequence type ST167 and novel in silico serotype O89b:H9.
Comparison of the genomes of Sanji with other ST167 strains revealed distinct sets of different plasmids, mobile IS elements, and antibiotic resistance genes in each genome, indicating that there exist multiple paths toward achieving XDR. The emergence of these pathogenic ST167 E. coli strains with diverse XDR capabilities highlights the difficulty of preventing or mitigating the development of XDR properties in bacteria and points to the importance of better understanding of the shared underlying virulence mechanisms and physiology of pathogenic bacteria.
DOI: https://doi.org/10.1128/mSystems.0024...
Title: Comparative Genome Analysis of an Extensively Drug-Resistant Isolate of Avian Sequence Type 167 Escherichia coli Strain Sanji with Novel In Silico Serotype O89b:H9
Authors: Xiancheng Zeng, Xuelin Chi, Brian T. Ho, Damee Moon, Christine Lambert, Richard J. Hall, Primo Baybayan, Shihua Wang, Brenda A. Wilson, Mengfei Ho
Editor: Nicola Segata
Published in mSystems® on 26 February 2019
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