As VR and AR are reaching technological maturity, mass awareness, and growing adoption, there is an increasing need to connect Neuro- and Cognitive-Sciences with hardware and software interface development. Digital tools are distributed in 3D space and have volumetric appearance, colocated audio, manipulability and in some cases, haptic identity. In this talk, we will discuss how neuroscience and spatialized digital information will synergistically scale human-machine interaction and potentially improve performance in real-world tasks.