Proteomics Reveal Aging Differences in Werner Syndrome Mouse Model | Aging-US
Aging-US #published this #researchpaper as the #cover for Volume 16, Issue 10, entitled, "Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model" by researchers from the Centre de recherche du CHU de Québec, Faculty of Medicine, Université Laval, Québec City G1V 4G2, Canada; Quebec Heart and Lung Institute, Faculty of Medicine, Université Laval, Québec City G1V 0A6, Canada. @chudequebec @IUCPQ
#aging #wernersyndrome #proteomics #liver #openaccess #openscience #research #peerreview #journal #publication #publishing #meded
DOI - https://doi.org/10.18632/aging.205866
Corresponding author - Michel Lebel - [email protected]
Abstract
Werner syndrome (WS) is a progeroid disorder caused by mutations in a protein containing both a DNA exonuclease and DNA helicase domains. Previous studies indicated that males lacking the helicase domain of the Wrn protein orthologue exhibited hepatic transcriptomic and metabolic alterations. In this study, we used a label-free liquid chromatography-tandem mass spectrometry approach to uncover proteins abundance associated with specific biological processes that differed depending on the age (four or ten months) and/or the genotype (wild type or Wrn mutant) in the serum and liver of mice. Principal component analysis of the proteomic data from both serum and hepatic tissue revealed a sexual dimorphism regardless of the age and the genotype of the mice. Moreover, although all Wrn mutant mice exhibited fatty liver by the age of ten months, a significant age and genotype dependent enrichment of proteins involved in lipid and fatty acid metabolic processes were uncovered only in males. Also, a genotype dependent increase in serum oxidant detoxification processes was observed in the serum of Wrn mutant males. Despite these sexual differences, several aspects of the immune system were affected in both females and males. Finally, an increase of specific immunoglobulin molecules was common in the liver and serum of both older Wrn mutant females and males. Such results suggest that specific immunoglobulin variants maybe associated with fatty liver progression in WS.
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Keywords - aging, proteomics, Werner syndrome, fatty liver, sexual dimorphism, immunoglobulins
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Aging publishes research papers in all fields of aging research, including but not limited to aging processes (from yeast to mammals), cellular senescence, age-related diseases (such as cancer and Alzheimer’s disease) and their prevention and treatment, anti-aging strategies and drug development, and, importantly, the role of signal transduction pathways in aging (such as mTOR) and potential approaches to modulate these signaling pathways to extend lifespan.
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