This is still a work in progress. I'm still facing some issues while launching certain games.
You need d2x cios/hermes cios. Once d2x cios is installed you can launch backups and make sure to change your loader cios to 222 or 223 In order to see your drive. Hermes is required to do this properly.
222 is giving me a few problems where sometimes the screen will hang and the hardrive will try to initiate. Upon launching puss in boots. Sometimes it would also randomly format my sd card? lol. Always keep a backup.
I switched to 223 and I havent had any problems(except PIB)
480 Pixel patching has been disabled to prevent black screen from booting. all of this has been done on a 4.3e pal wii
Links:
https://gbatemp.net/threads/usb-loade...
https://gbatemp.net/threads/does-anyo...
/ can_you_use_2_usb_drives_in_usbloadergx
It is possible. Just takes finding the right settings to make this work :)