Two medications that quickly lower blood pressure. Captopril-Darnitsa is a combination antihypertensive medication containing a dosed combination of captopril and hydrochlorothiazide. How is Captopril different from Captopril? Captopril contains hydrochlorothiazide. Hydrochlorothiazide is a moderate-strength thiazide diuretic intended for the treatment of edema of various origins (congestive heart failure, liver cirrhosis with ascites, nephrotic syndrome, chronic renal failure, premenstrual syndrome, and fluid retention in obesity). Captopril is a medication for high blood pressure; its active ingredient is Captopril. Captopril prevents vasoconstriction and stimulates aldosterone secretion in the adrenal glands. However, older adults can take other medications. What blood pressure pills are best for older adults? Possibly enalapril, but always consult your doctor before using any medication.