Laser Beam via "Botched" Pick Off
I figured this out while conducting experiments on how to potentially cheese Petey 5 Catches. Unfortunately it doesn't seem like picking runners off can help out Petey, but it turns out you can use this technique to acquire an out via the Laser Beam - it's even possible to get pitcher laser this way! Waluigi is unboosted in this video but I suspect that we still need the Lucky Glove to get a laser out on Noki, so ultimately this probably doesn't change very much, but is a way to take hit trajectories out of the equation, and that's not nothing. One could plausibly HBP a batter and then laser them into oblivion immediately after. DK comes to mind as someone who could potentially benefit from this, in addition to Waluigi (Pianta's probably fine with current strats).
The key is to have no runner on second and slow fielders at 2B and SS. Hold up, and then press A immediately after B to initiate the pick and throw the ball past second base. This sets you up as if you'd gotten a hit to CF like normal, except that there doesn't seem to be a way to extract Big Plays or "catches" from this scenario no matter how you do it - just the Laser Beam out. Sliding into the botched throw didn't trigger a scoop Big Play either.
I'll do a little more testing to see if you can cheese Tag Out and Jumping Catch with this. Those are the only two other things I can see this technique being useful for, but I'll of course keep brainstorming. Let me know if you have any ideas about how to exploit pick-offs for defense missions!