Acquired Coagulation Defects (Pathophysiology) | Sketchy Medical
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Grab your dice and gear up for a DnD adventure where we tackle the beast known as Disseminated Intravascular Coagulation (DIC)—a condition that devours everything in its path: coagulation factors, platelets, and red blood cells.Often triggered by major illnesses like gram-negative sepsis, DIC creates a dangerous cycle of bleeding and clotting, with symptoms like ecchymoses, mucosal bleeding, and potential thromboses. We'll explore how DIC presents with elevated PT, PTT, bleeding time, D-dimer, and more. Treatment involves replacing what's missing and tackling the underlying cause. We also touch on Vitamin K deficiency, a more benign condition, common in newborns and adults with malabsorption issues, where treatment includes vitamin K replacement or fresh frozen plasma in urgent cases.
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