Beyond affinity: antibody discovery, optimization, and developability screening from mammalian....
Presented By: Peter Slavny, PhD
Speaker Biography: Peter Slavny, CTO at IONTAS and co-founder in 2012, is responsible for delivering the antibody discovery & protein engineering portfolio. Peter has led numerous successful biotherapeutic drug discovery campaigns, with several resulting molecules now entering the clinic. Before this, Peter held an academic (“post-doc”) position in Cambridge University and earned a Ph.D. in molecular biology (John Innes Centre, Norwich).
Webinar: Beyond affinity: antibody discovery, optimization, and developability screening from mammalian display libraries
Webinar Abstract: Clinical drug candidates must have not only appropriate affinity and target specificity, but also optimal biophysical properties. Using nuclease-directed integration, we constructed large mammalian display libraries where each cell contains a single antibody gene inserted at a single locus. IgG-formatted antibodies are displayed on the surface, permitting selection from the library of clones by FACS, which allows the selection for desirable binding properties in the final format.
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