Pay close attention to antlion workers, they can easily kill you or Alyx in one or two shots. The regular Antlion Guard deals 150 damage, while the toxic guard will kill you outright no matter what, avoid their melee attacks at all costs. They are especially tanky on the highest difficulty, you need to use the gravity gun as those props still do a lot of damage, shotgun double shots as they are more cost efficient than single shots and .357 magnum as it has less damage reduction, SMG grenades and regular grenades deal a some heavy splash damage to both of them when they are close together.
Pay close attention to Zombines. They are very fast and durable. Gravity gun is the most effective weapon for most zombie encounters.
The most effective weapon against hunters is the gravity gun as well, as it is not affected by damage reduction. Be careful when using heavy props, your movement speed is slowed considerably.
Mod link: https://www.moddb.com/games/half-life...