GCA and Current Clinical Trials 2024
0:00
1:06 Introducing Sebastian Unizony, MD.
2:39 What is Giant Cell Arteritis (GCA)?
4:28 How GCA commonly presents.
9:46 Options to make a diagnosis.
12:34 Current treatments.
13:38 Questions about GCA.
14:20 Q: After being on a treatment plan for two years with no flares is there a chance of losing vision as prednisone is reduced?
16:42 Q: Temporal artery ultrasound and other advanced imaging techniques are they not subject to the “skipping” that biopsies can be subject to, and miss the diagnosis?
18:18 Q: What is the most common diagnostic test used for monitoring ongoing disease?
20:11 Q: Are there any genetic depositions for GCA?
21:38 Q: Can you talk about the relapse rate for GCA?
23:57 Audience Survey: Experience with clinical studies.
25:06 Understanding clinical trials.
26:27 Studying treatment options for GCA.
27:08 Understanding random controlled trials (RCT)
28:23 Clinical Trials 101-- A Glossary.
34:46 Ethical and scientific principles and guidelines.
38:30 Vasculitis clinical trials.
39:41 Recent clinical trials, current clinical trials, future perspectives.
40:34 Abatacept (orenica) for GCA.
41:25 Mavrilimumab for GCA.
42:06 Secukinumab (consentyx) for GCA.
43:53 Ongoing study of abatacept.
44:13 Ongoing study of upadacitinib (rinvoq).
44:20 Ongoing study of guselkumab (tremfya).
44:37 Ongoing study of tozcilizumab and methotrexate.
44:52 GUSTO Study (Switzerland) Can we use less than six months of steroids?
47:30 Ultimate goal of clinical trials in GCA in the near future.
49:03 Three online resources.
50:06 What is the difference between clinical studies and research?
51:27 Are newly diagnosed patients allowed to participate in clinical studies?
What role does a treating physician play in clinical studies?
54:27 Why should I participate in a clinical study if my current treatment protocol is working?
57:21 Are there any post-morten studies being conducted?
58:47 Thank you and wrap up.
GCA and GCA Clinical Trials
Recorded January 2024
A diagnosis of Giant Cell Arteritis (GCA) often brings more questions than answers. It also presents an opportunity for patients to change the trajectory of living with this disease for themselves and others. As patients seek to navigate this disease, they can join the collective effort for better treatments and a cure by participating in research, like the current GCA clinical studies through the National Institute of Health (NIH).
In this one-hour live webinar, Sebastian Unizony, MD, will take audience questions about GCA. He will also discuss some of the exciting GCA clinical research studies.
You will learn:
· A brief, clinical overview of GCA, covering diagnosis, treatment, and management of this vasculitis. A Q&A will follow the presentation.
· What is typically involved in clinical studies and why patient participation is so critical for their success?
Finally, Dr. Unizony will discuss a few of these studies especially focused on GCA.
Download a PDF copy of the webinar presentation: https://www.vasculitisfoundation.org/...
Expand your knowledge of vasculitis. Visit the Vasculitis Foundation website at: https://www.vasculitisfoundation.org/