Fisetin Failed In The ITP Trial. Was It The Dosage?
Here we review the result for fisetin in the recent ITP paper. Fisetin, a senolytic, did not extend median or total lifespan in the mice and also did not clear the senescent cells. We look at the data and doses used.
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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
https://link.springer.com/article/10....
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#fisetin #senolytics #itp