I deep clean my PC once during the first month of every year due to time constraints.
I take out everything inside the case, then clean them one by one using brushes of varying sizes, an air blower for the AIO's radiator, clean room wipers for sensitive components like PCBs, and the CPU/cooler's IHS, (I used to just use paper towels for those), a few cleaning cloths, a few Lysol surface cleaners, and a glass cleaner for the case.
I also disassemble the GPU to re-apply some thermal paste, and to better clean the heatsink fins and fans, then re-apply some thermal paste on the CPU as well.
I have also added another SSD to my build.
So now, I have 1x SATA HDD, 2x SATA SSDs and 3x M.2 NVME SSDs.
1x Samsung 870 EVO 500GB
1x Samsung 870 EVO 1TB
1x WD Black SN750 500GB
1x WD Black SN850 1TB
1x WD Black SN850X 2TB
1x WD Black 2TB HDD