Li advances work on HIV vaccine
Li advances work on HIV vaccine
A Husker virologist has received a grant from the National Institutes of Health to advance the 40-year quest to develop a vaccine against HIV, which infects about 40 million people globally and has caused an estimated 42 million deaths since the epidemic began.
Qingsheng Li, Willa Cather Professor of biological sciences and a member of the Nebraska Center for Virology at the University of Nebraska–Lincoln, recently received a five-year, $3.5 million R01 grant from the NIH to advance work on an mRNA vaccine against HIV. His approach may overcome what has been one of the most intractable obstacles in the field: the virus’ ability to rapidly mutate, which has led to hundreds of thousands of HIV strains. By targeting parts of the virus that are consistent across this vast genetic diversity, Li’s formula has potential to achieve a level of efficacy that has so far eluded the field.
The formulation of mRNA packaged inside lipid nanoparticles is also novel for its temperature stability. Vaccines using mRNA typically require ultralow temperatures offered by specialty freezers, which are scarce in developing countries. Li’s design would enable storage for several months at about 4 degrees Celsius — the temperature of an average refrigerator.
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