Misinformation about Ivermectin arm of PRINCIPLE trial for Covid-19

Опубликовано: 14 Сентябрь 2026
на канале: Biotech and Bioinformatics with Prof Greg
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There's been some confusion and misinformation about the Oxford PRINCIPLE trial for Covid-19 treatments, which includes ivermectin, but for which for a time had put their ivermectin treatment arm on hold. The confusion has been amplified recently on social media as misinformation; this video is to clear up the issue.

Bottom line: the arrow of time runs in one direction!

Side note for clarity: to date, there has NOT been consistent evidence showing a benefit from Ivermectin for Covid-19 patients.

Note: this video is an updated version of a video I uploaded an hour ago. I amended it because of the excellent additional information provided by @Percy Phelps, which I thought was worth including.

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▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
0:00 Introduction
0:38 The PRINCIPLE trial
1:18 About the study: 10 February 2022
1:42 MEDPAGE today article from December 2021
2:20 Web archive snapshot of "PRINCIPLE trial: About the study" 24 January 2022
3:10 Confirmation of PRINCIPLE trial ivermectin arm pause by BIRD group email
3:37 Confirmation of trial arm pause by PRINCIPLE trial itself
4:05 Why should there be a supply issue?

▬ Disclaimers ▬▬▬▬▬▬▬▬▬▬

This video is for educational purposes only.

I have no conflicts of interest. I do not receive any compensation or support from any company making or developing Covid-19 vaccines or novel therapies. I made this video on my own time and with my own money and equipment, with no incentives or sponsorship (though you can buy me a coffee).

▬ About this channel ▬▬▬▬▬▬▬▬▬▬

I'm Greg Tucker-Kellogg, PhD, a biology professor in Singapore with a career spanning both biotechnology and academia. Videos on this educational channel cover some of my scientific and teaching interests in genomics, bioinformatics, and biochemistry, as well as topics in current scientific issues of public interest. Links to my professional profile are available in the "about" section of the channel.


▬ References ▬▬▬▬▬▬▬▬▬▬

About the PRINCIPLE trial and how to join https://www.principletrial.org/partic...
Web archive snapshot of the same page, January 24, 2022 https://web.archive.org/web/202201240...
December 14 article from MEDPAGE today https://www.medpagetoday.com/special-...
Dec 22 2021 web archive of PRINCIPLE trial, showing Ivermectin arm on hold for temporary supply issues https://web.archive.org/web/202112222...
Dec 24, 201 web archive of BIRD letter to Professor Chris Butler of the PRINCIPLE trial about the temporary pause https://web.archive.org/web/202112241...