Ivermectin not effective for Covid-19 progression: I-TECH clinical trial results
The results of the I-TECH clinical trial on Ivermectin for Covid-19 were published in JAMA Internal Medicine last week, with no efficacy seen for Ivermectin in treating Covid-19 to prevent progression to serious disease. In this video I'm going to go over an outline of the trial design, a discussion of sample size calculation, a discussion of results, and touch on some of the misinformation and "spin" that has come out regarding this trial in the last week.
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▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
0:00 Introduction
0:32 Introduction to the I-TECH trial
5:02 Sample size estimation in clinical trials
14:00 I-TECH trial results
22:40 How the negative trial results are being spun by Ivermectin advocates
▬ Disclaimers ▬▬▬▬▬▬▬▬▬▬
This video is for educational purposes only.
I have no conflicts of interest. I do not receive any compensation or support from any company making or developing Covid-19 vaccines or novel therapies. I made this video on my own time and with my own money and equipment, with no incentives or sponsorship (though you can buy me a coffee).
▬ About this channel ▬▬▬▬▬▬▬▬▬▬
I'm Greg Tucker-Kellogg, PhD, a biology professor in Singapore with a career spanning both biotechnology and academia. Videos on this educational channel cover some of my scientific and teaching interests in genomics, bioinformatics, and biochemistry, as well as topics in current scientific issues of public interest. Links to my professional profile are available in the "about" section of the channel.
▬ References ▬▬▬▬▬▬▬▬▬▬
Lim SCL, Hor CP, Tay KH, et al. Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial. JAMA Internal Medicine. Published online February 18, 2022.https://doi.org/10.1001/jamainternmed...
Tushar VS Sample Size Estimation in Clinical Trial Perspect Clin Res. 2010 Apr-Jun; 1(2): 67–69.
https://www.ncbi.nlm.nih.gov/labs/pmc...