Isaac Clarke pointedly, then fatally shows Hammond that he is not a nuclear engineer when he is tasked by the latter to eject a 12-megaton warhead from the USM Valor.
Just a quick video highlighting one of Isaac's best lines in the game (voiced to perfection by the legendary Gunner Wright), and the hilarious turn of events if Isaac does not exercise caution in the torpedo bay (hint: Kinesis is your friend in that room).