Using Polarizable Force Fields and Accelerated Molecular Dynamics to Investigate Troponin C
The protein Troponin (Tn), part of the thin filament in cardiomyocytes, plays an important role in calcium signaling events in cardiac muscle contraction, acting as a Ca2+-dependent switch. Here OpenMM 2012 Visiting Scholar Steffen Lindert describes his project to improve the modeling of calcium binding to its binding protein troponin C (TnC) and his experiences as a visiting scholar.