Sanada was born in Tokyo. Originally planning to be an action star, he studied Shorinji Kempo and later took up Kyokushin kaikan karate. Sanada began training at the age of 11 with actor and martial arts star Sonny Chiba's Japan Action Club, where he developed good all-round martial arts ability, and soon became Chiba's protégé. Sanada's martial arts film career introduced him to Michelle Yeoh, with whom he later starred in Danny Boyle's Sunshine.Some of Sanada's more famous movies are Tasogare Seibei (The Twilight Samurai), Ring, Kaitō Ruby, and The Last Samurai. Sanada played Matsuda, the Japanese imperialist who befriends Ralph Fiennes's character, in the 2005 film The White Countess, directed by James Ivory. He starred in the Chinese film The Promise directed by Chen Kaige as General Guangming. Sanada has appeared in Rush Hour 3 with Jackie Chan and Chris Tucker and in 2007's The City of Your Final Destination, another James Ivory film, in which he plays the younger lover of Anthony Hopkins's character.