Susan Sharfstein - Understanding the factors that control productivity in CHO cells
This video details the research of Prof. Susan Sharfstein on “Understanding the factors that control productivity in CHO cells”
Prof. Sharfstein is a Professor of Nanobioscience (SUNY Polytechnic Institute, Albany, NY USA) and Fulbright Visiting Scholar at the NICB, DCU (Sept.-Dec. 2017).
Her research focus is on understanding the role of culture conditions and cell physiology on use of living systems for industrially relevant processes, with a primary interest in the use of mammalian cell systems for the production of therapeutic proteins and carbohydrates. Current projects are focused on the production of heparin in Chinese Hamster Ovary (CHO) cells, characterizing CHO cell clones producing recombinant monoclonal antibodies to identify factors that affect productivity, the effects of osmolarity on monoclonal antibody production in CHO cells, and the effects of growth rate on cell physiology in Escherichia coli, as well as in using nanotechnology to better understand cultured cells and bioprocesses. Current projects are focused on patterning cells on surfaces for high throughput delivery of silencing RNA and development of novel biosensors for use in bioreactors.
This seminar took place at 1pm on Tuesday 3rd October 2017 in the NICB seminar room. This video was created with the help of senior NICB PhD. student (CHO Biopharma) Prashant Kaushik.