How to Become More Metabolically Flexible | Zone 2, Fasting, & Molecules That Shift Your Fuel Use
Most people focus on being metabolically healthy—but overlook the deeper metric that drives lasting energy and performance: metabolic flexibility.
In this clip from a recent episode of Beyond Healthspan, Dr. Richard LaFountain and Brandon Fell explain what it really means to be metabolically flexible—your body’s ability to switch seamlessly between burning fat and carbohydrates based on what life demands.
They break down:
Why metabolic inflexibility leads to energy crashes and poor performance
How to use Zone 2 training to increase fat oxidation and mitochondrial health
The impact of fasted exercise, carb timing, and fuel transporters like CD36 & CPT1
The role of oxytocin, SGLT2 inhibitors, and metformin in restoring flexibility
Why training across multiple heart rate zones—not just high intensity—is key
How to structure your training and nutrition for better energy, adaptation, and aging
Whether you’re an athlete, a weekend warrior, or just trying to avoid the 2PM crash—this is what you need to know to train your metabolism to respond better, burn smarter, and fuel longer.