With PTC Mathcad Prime 10, you can now apply subscript or superscript formatting to any text within a text box or a text block. You can select subscript or superscript from the Mathcad ribbon UI (Text Formatting tab) while in a text region, and type, or use the keyboard shortcuts ctrl + - and ctrl + +, respectively.
The subscript/superscript commands in the Text Formatting tab are premium functionality that you need a paid license to use. However, you can get around that restriction for thirty days by signing up for the Mathcad Prime free trial at https://www.mathcad.com/trial