Robustness, LOD and LOQ in Chemistry
LOD It is the lowest limit of the analyte that can be detected but can not be quantified in the sample.
It is given as percentage or in ppm
LOD = 3.3 x SD/Slop
SD standard deviation
Slop from calibration curve
LOQ It is the lowest limit of the analyte that can be detected but can be quantified in the sample.
It is the ratio of 1:10
LOQ = 10 x SD/Slop
SD standard deviation
Slop from calibration curve
It is the lowest limit of the analyte that can be detected but can be quantified in the sample.
It is the ratio of 1:10
LOQ = 10 x SD/Slop
SD standard deviation
Slop from calibration curve
Robustness
It is the ability of analytical procedure to remain unaffected by the small but delibrate variations in the parameters like pH, temperature, instrument and composition of solution.