Organocatalyzed Synthesis of Bioactive Nitrogen Containing Heterocyclic Compounds
Organocatalyzed Synthesis of Bioactive Nitrogen-Containing Heterocyclic Compounds via C-H Bond Activation Under Solvent-Free Conditions
Lalita Devi and Kamal K. Kapoor*
*Department of Chemistry, University of Jammu, Jammu-180006, J&K, India
E-mail: [email protected], [email protected]
Heterocyclic compounds have found a key role in most fields of sciences especially in medicinal chemistry due to their usage as drugs for various diseases. Many biological molecules such as DNA and RNA, vitamins, hemoglobin, chlorophyll contain heterocycles as their major skelton. Nitrogen containing heterocycles have occupied a prominent place because of their diverse pharmacological activities such as anti-fungal, anti-bacterial, anti-oxidant, anti-allergic, anti-cancer, anti-malarial, anti-inflammatory, anti-convulsant, anti-HIV etc. Among the various classes of nitrogen containing heterocyclic compounds, quinoxalinone derivatives have gained considerable attention as these can be utilized as a building block for designing useful compounds of potential pharmaceutical interest. Literature reports available for their synthesis offer various disadvantages such as use of toxic reagents, harsh reaction conditions, longer reaction times, tedious work up, generation of huge amounts of waste products, etc. In order to overcome these disadvantages, there has been extensive interest in the development of newer approaches to prepare quinoxalinone based heterocyclic motifs. In the oral presentation, synthesis of quinoxaline derivatives using ecobenign, cost effective, stable and easy to handle methodologies for utilizing them further in the synthesis of variety of biologically potent derivatives will be discussed.
Keywords: Quinoxalinone, quinoxalinone derivatives, solvent free synthesis, ecobenign