What is the variant report and how to use it
Welcome to MTHFR Support™.
In this video we will be introducing the variant report.
The variant report is one of our most popular cornerstone genetic reports.
With the variant report you can use your 23andme, Ancestry and many other raw data genetic files to create a gene report with over 1000+ genes.
With this powerful report you can gain significant insights to your health and genetic mutations.
When you purchase the variant report, the report is easily downloaded from Sterling's App and you can save it as a PDF file.
The best place to work with your variant report is inside of Sterling’s app because you can interact with the report using the Tag search and SNP search.
However, using the report on its own is also very useful because of the amount of data available and your ability to quickly look up areas of interest to your health.
The variant report is a breakdown of all the genes that were tested by your ancestry provider.
The variant report breaks up your genes into useable data, for example, in this variant report there are 47 pages of genetics and an additional 11 pages with genetic pathway diagrams that help you with understanding the pathways for your genes and any mutations you may have.
The first thing to note is that your variant report shows your genes in three colours, the green genes mean there is no mutation, a yellow gene is considered a heterozygous gene mutation and a red gene is considered a homozygous gene mutation.
Often a yellow or heterozygous gene mutation is considered a half copy, that’s why you will see a +/- sign beside it, while a red or homozygous gene mutations can be considered as a double copy with a +/+ sign beside it.
The next important part of the report is the heading topics. These headings in blue tell you what the genes you are looking at are associated with. As you can see the first topic heading covers Alzheimer’s, cardio and lipids.
As we scroll through to page 4 we now have a new topic, COMT Activity, you will also note that beside COMT Activity it says (Figure 1), this is to let you know that for all COMT genes there is a COMT pathway diagram that works with this section of the report.
To access the (Figure 1) COMT pathway diagram you simply click on the bookmarks tab of the variant report, this will then reveal all of the heading topics of the report and by scrolling down on the bookmarks menu and clicking on figure 1 you can now see the associated diagram that is associated with the COMT genes and their mutations.
Now you can see the COMT diagram you can see the flow of how the COMT gene works.
When you see that you have multiple gene mutations in COMT you can use this diagram to understand how you might be reacting with these mutations and work out what treatments, tests and ideas will work best for you.
As you can see looking through the bookmark section and all the titles, there is many useful ways to view your variant report including the more popular pathways including the methylation and homocysteine pathways, phase 1 and 2 liver detox, neurotransmitters, immunity and many more, including 11 advanced diagrams that make understanding your genetics much easier.
While the variant report is easy to use, especially inside Sterling’s App, we do recommend getting assistance from a practitioner who understands epigenetics and nutrigenomics.