Making the essence of allergies!
Warning: Do not attempt anything shown in this video. This content is for educational and entertainment purposes only.
In today's video, I'll be making histamine, also known as the essence of allergies! Histamine does a bunch of things in the body, but it is mainly known for causing the itching, swelling, and other annoying symptoms you get during an allergic reaction.
I go through the synthesis, run into some annoying crystallization problems, and eventually end up with a clean sample of histamine dihydrochloride!
Enjoy! :)
Chapters:
00:00 Histamine synthesis plan and biological role
01:46 Acetophenone starting-material purification
03:32 Histidine decarboxylation setup
05:19 Imine-catalyzed decarboxylation reaction
07:01 Reaction cleanup and intermediate processing
08:42 Histamine dihydrochloride extraction
10:28 Histamine purification and recrystallization
12:17 Product isolation and final yield
13:58 Melting-point characterization and effects
Sources:
Info on histamine: https://en.wikipedia.org/wiki/Histamine
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