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The body is incapable of directly using folate (B9).
Folate in its “raw form” must first undergo a conversion into methylfolate through a process referred to as the one carbon pathway, before it can be used for its various purposes in the body. Genetically some of us have a greater ability to convert folate into its usable form than others.
Learn your status for this pathway: https://mygenefood.app/
Methylfolate is the biologically active form of vitamin B9.
Taking too much methylfolate can cause side effects, such as severe anxiety, nausea, insomnia, migraines, irritability, achy joints, headaches, and more: https://www.mygenefood.com/blog/are-y...
Clinical studies show that three different types of responses to methylfolate supplementation exist:
Response 1: A person feels great on methylfolate, with previous symptoms mostly gone.
Response 2: A person is active, alert, and starts to feel great, but unpleasant symptoms such as anger, intense muscle aches, joint pain, and anxiety appear in the second week.
Response 3: After a short duration of supplementation or even a small amount of methylfolate causes multiple side effects.
In this video, Dr. Neil Nathan discusses why less may be more when it comes to finding the optimal methylfolate dose.