Evolution of Flow Cytometry in Infectious Disease Research
This panel discussion will focus on the use of advanced flow cytometry, within four pathogenesis aspects, of the human body response to infectious diseases: Infection and Replication, Antibody Response, Post Infection and Protective Immunity.
Hear how our panelists study the various infection stages and the directions of their studies of infectious diseases.
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0:22 the membrane proteome array is essentially an array of human membrane proteins that are expressed in cell lines and we can use flow cytometry to detect many things with those cells expressing including antibody binding so one of the main projects we do with the membrane proteome array is test therapeutic lead antibodies for off target specificity
0:49 we discovered the original antibodies that would then go into a panel like that so we utilize flow cytometry to discover those initial binders and so we rely on that very heavily because going you know beyond just infectious diseases many it's not the majority of targets nowadays are self-service receptors um and so we find a lot of value in screening candidates up front against that endogenous version of the protein expressed on the cell surface but that's critical for accurate presentation um and to discover the most high quality lead binders
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