JID February 2024 Cover: SARS-CoV-2 from Skin Lesion to Ultrastructure
COVID-19; SARS-CoV-2; Spike protein; Vasculitis; Immunofluorescence; Electron microscopy; Dermatology
Overview of SARS-CoV-2-Related Vasculitic Skin Lesions: A comprehensive journey from clinical images to ultrastructure. Dermal vascular cell destruction is evident in H&E staining, while electron microscopy reveals the presence of autophagosomes. Immunofluorescence images showcase spike protein depositions in COVID-19-associated autophagosomes of dermal microvascular cells. Staining details for immunofluorescent images: SARS-CoV-2 spikes (blue), LC3B (red), LC3C (green), DAPI (gray).
Video courtesy of Simon Riel, Core Facility for Electron Microscopy, Department of Dermatology, University Hospital Tübingen, Germany.