IMCCRT-2024-8133 Title - Exploring the therapeutic intervention of propolis on brain: Propolis
Title - Exploring the therapeutic intervention of propolis on brain: Propolis Supplementation regulated oxidative stress level in Prepubertal and Adolescent stressed Rats
Author's Name - Imane Kherrab, Abdelhalim Mesfioui, Aboubaker Elhessni.
Abstract - Collected evidence highlights the strong effect of propolis due to its benefits on neurobiological enhancement. Chronic stress in prepuberty and adolescence periods has critical effect in adult age inducing various diseases, mood disorders and inflammatory pathologies. This study aims to investigate the effect of unpredictable chronic mild stress (UCMS) and methanolic extract of propolis (MEP) supplementation on nitric content as oxidative stress parameter. For this evaluation, rats were randomly divided into three groups including control group. Stressed group was exposed to UCMS for 6 weeks. The treated group received 200 mg/kg/day for 2 weeks. Our data shows that stress in prepuberty and adolescence increased the level of nitrite content in the prefrontal cortex and hippocampus. Thus, the supplementation with propolis effectively reversed these results. These findings suggest that the strong regulation effect of propolis extract is linked to its anti-oxidative properties.
Keyword's - propolis, brain, unpredictable chronic mild stress, oxidative stress, antioxidant activity