Glucosamine are not statistically significant to Knee degeneration!!
In fact, there are several highly credible studies on the efficacy of glucosamine in the treatment of "degenerative" knee arthritis: the first is a comprehensive article published in the American Journal of Family Physicians, To date, glucosamine is one of the most widely used nutritional supplements in the United States, although there is no evidence that it slows or prevents joint degeneration, and there are no reports of serious side effects.
As a result, physicians have no reason to oppose the use of large-scale research programs led by the National Institutes of Health (NIH). The more suitable principle is: Let the patient try to take 2 months, after the decision by the patient whether to continue to use, the physician's responsibility is to observe the therapeutic effect and whether adverse reactions occur.
Experiments show that health food can not slow joint degeneration
Unexpectedly, the first NIH large-scale research report released after 2 months, the result was: can not prove to accept glucosamine, chondroitin and non-steroidal anti-inflammatory agents and other treatment, can slow down the knee "degradation ".
This NIH report is the first study of a large-scale study of the clinical efficacy of glucosamine. A group of researchers, led by the Utah State University School of Medicine in Salt Lake City, Utah, combined a group of nine medical centers for 572 patients with Stage 2 or Stage 3 degenerative knee arthritis who were randomly assigned to 5 groups (Group 1: daily administration of 1500 mg of glucosamine; Group 2: daily administration of 1200 mg of chondroitin; Group 3: combination of the above two preparations; Group 4: daily treatment with either Taking the non-steroidal anti-inflammatory agent Celebrex 200 mg; Group 5: using Placebo as a placebo when the control group).
In the control group, the intervertebral space was reduced by an average of 0.166 mm
After treatment for 2 years, the changes of the joint space before and after treatment were compared. The results showed an average reduction of 0.166 mm in the intervertebral space of the fifth group (ie, the control group). In contrast, no group of treatments was found to yield better results than the control group. That is, for moderately "degenerated" knee joints, there is no evidence that the joints are "degraded" during the 2 years of treatment described above.
Two years later, another report of the same series was released, this time for 662 patients, who were equally randomized into five groups as described above. After 2 years of treatment, the pain and functional improvement were compared before and after treatment. No statistically significant effect was observed in the first four groups compared with placebo in the fifth group.
On cartilage hyperplasia are not statistically significant
The same year, the University of Bern, Switzerland published another conclusion similar to the report in the results for the 3803 patients were analyzed and found that compared with placebo, whether it is glucosamine, chondroitin, or its mixture, Pain and cartilage hyperplasia have no statistically significant therapeutic effect. Therefore, they recommend that medical professionals and health insurance providers stop using or subsidizing treatment in this regard.
In fact, glucosamine and related oral nutritional supplements (such as chondroitin) in the treatment of "degenerative" knee arthritis, in addition to the traditional "eat Han make up the psychological effect", these products are similar anti-inflammatory analgesic drugs Of the quick, anti-inflammatory to relieve pain symptoms, in just a few days let the user feel the effect. However, there is no credible study to date confirming that long-term use of these supplements can alter the natural course of degenerative knee degeneration.